Foscarnet is a synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis. Foscarnet is the conjugate base of a chemical compound with the formula ho 2 cpo 3 h 2. Infusions of foscarnet 120 to 200 mgkgday for up to 4 weeks are given for aciclovirresistant herpes virus infections. Foscavir injection is a sterile, isotonic aqueous solution for intravenous administration only. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. A type of abnormal heartbeat prolonged qt interval has happened with foscarnet. Composicion, indicaciones, presentacion y contraindicaciones. Foscarnet richet indicaciones, dosificacion, presentacion.
Foscarnet sodium has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Intravitreal administration to patients with cmv retinitis has been reported. Efficacy of intravitreal foscarnet in a patient with aids. Double blind, placebo controlled, multicentre study. Low white blood cell counts have happened with foscarnet. Jan 26, 2020 a type of abnormal heartbeat prolonged qt interval has happened with foscarnet. Dec 11, 2012 foscarnet dosages must be adjusted according to renal function. Foscarnet has in vitro activity against human herpesvirus 6a and 6b, and has been used in a few cases. Foscarnet definition of foscarnet by the free dictionary. It is classified as a pyrophosphate analog dna polymerase inhibitor. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with a molecular formula of na 3 co 5 p6 h 2 o and a molecular weight of 300. Antivirales universidad centroccidental lisandro alvarado. Each milliliter of foscavir contains 24 mg of foscarnet.
Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula of na3co5p6 h20 and a molecular weight of 300. Pdf topical treatment of recurrent genital herpes simplex. Activity of penciclovir in antiviral assays againts herpes simplex virus. Foscarnet sodico dosificacion, efectos secundarios infosida. Foscarnet definition is a hydrated sodium salt na3co5p6h2o that is administered intravenously to individuals infected with hiv to treat retinitis caused by a cytomegalovirus. Foscavir has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Penciclovir, ganciclovir, trifluridina, idoxiuridina y vidarabina. Foscarnet definition of foscarnet by merriamwebster. Jul 22, 2019 foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with a molecular formula of na 3 co 5 p6 h 2 o and a molecular weight of 300. Foscarnet phosphonomethanoic acid is an antiviral medication which is primarily used to treat viral infections involving the herpesviridae family.
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